| 1. Round | 09/01/2023 | Club Tijuana | - | Cruz Azul | 1:1 |  |
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| 2. Round | 15/01/2023 | FC Juárez | - | Club Tijuana | 3:0 | ||||
| 3. Round | 21/01/2023 | Club Tijuana | - | UANL Tigres | 1:1 |  |
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| 4. Round | 28/01/2023 | Club Tijuana | - | Pumas UNAM | 0:0 | ||||
| 5. Round | 04/02/2023 | Club Necaxa | - | Club Tijuana | 1:1 | ||||
| 6. Round | 11/02/2023 | Club Tijuana | - | Atlético San Luis | 1:0 | ||||
| 7. Round | 16/02/2023 | Deportivo Guadalajara | - | Club Tijuana | 2:1 | ||||
| 8. Round | 20/02/2023 | CF América | - | Club Tijuana | 2:1 | ||||
| 9. Round | 27/02/2023 | Club Tijuana | - | CF Pachuca | 2:0 | |
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| 10. Round | 04/03/2023 | Club Tijuana | - | Atlas Guadalajara | 1:1 | ||||
| 11. Round | 13/03/2023 | Santos Laguna | - | Club Tijuana | 3:2 | |
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| 12. Round | 18/03/2023 | Club Tijuana | - | Deportivo Toluca | 3:3 | |
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| 13. Round | 02/04/2023 | CF Monterrey | - | Club Tijuana | 4:0 | ||||
| 14. Round | 08/04/2023 | Club Tijuana | - | Gallos Blancos | 1:2 | ||||
| 15. Round | 15/04/2023 | Mazatlán FC | - | Club Tijuana | 1:2 | |
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| 16. Round | 22/04/2023 | Club Tijuana | - | Club León | 0:0 | ||||
| 17. Round | 30/04/2023 | Puebla FC | - | Club Tijuana | 5:2 |
Argentina