| 7. Round | 01/03/2008 | Provincial Osorno (old) | - | Deportes Melipilla | 3:1 | ||||
| 9. Round | 08/03/2008 | O'Higgins | - | Deportes Melipilla | 1:1 | ||||
| 10. Round | 12/03/2008 | Deportes Melipilla | - | Deportes Concepción | 3:4 | ||||
| 11. Round | 16/03/2008 | Cobresal | - | Deportes Melipilla | 4:2 |  |
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| 12. Round | 23/03/2008 | Deportes Melipilla | - | Cobreloa | 1:2 | ||||
| 13. Round | 29/03/2008 | Universidad Católica | - | Deportes Melipilla | 2:0 | ||||
| 14. Round | 06/04/2008 | Rangers | - | Deportes Melipilla | 0:1 | ||||
| 15. Round | 13/04/2008 | Deportes Melipilla | - | Huachipato | 2:4 | ||||
| 16. Round | 19/04/2008 | Palestino | - | Deportes Melipilla | 2:1 | |
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| 17. Round | 27/04/2008 | Deportes Melipilla | - | Antofagasta | 0:1 | ||||
| 19. Round | 04/05/2008 | Deportes Melipilla | - | Universidad de Concepción | 3:1 | |
Chile