| 22. Round | 18/01/2022 | Konyaspor | - | Adana Demirspor | 1:0 |  |
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| 25. Round | 14/02/2022 | Adana Demirspor | - | Beşiktaş | 1:1 | ||||
| 26. Round | 20/02/2022 | Gaziantep FK | - | Adana Demirspor | 0:3 | ||||
| 27. Round | 25/02/2022 | Adana Demirspor | - | Antalyaspor | 0:0 | ||||
| 29. Round | 13/03/2022 | Adana Demirspor | - | Sivasspor | 2:3 | ||||
| 30. Round | 19/03/2022 | Adana Demirspor | - | İstanbul Başakşehir | 2:1 | ||||
| 31. Round | 04/04/2022 | Hatayspor | - | Adana Demirspor | 0:0 | ||||
| 33. Round | 17/04/2022 | Kasımpaşa SK | - | Adana Demirspor | 4:0 | ||||
| 34. Round | 23/04/2022 | Adana Demirspor | - | Trabzonspor | 1:3 | ||||
| 35. Round | 29/04/2022 | Giresunspor | - | Adana Demirspor | 2:0 | |
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| 36. Round | 07/05/2022 | Adana Demirspor | - | Alanyaspor | 1:2 | ||||
| 37. Round | 16/05/2022 | Galatasaray | - | Adana Demirspor | 3:2 | ||||
| 38. Round | 22/05/2022 | Adana Demirspor | - | Göztepe | 7:0 |
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