| 1. Round | 10/08/2016 | Fénix | - | Cerro Porteño | 1:0 | ||||
| 1. Round | 18/08/2016 | Cerro Porteño | - | Fénix | 2:0 |  |
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| 2. Round | 24/08/2016 | Cerro Porteño | - | Real Potosí | 6:0 | |
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| 2. Round | 15/09/2016 | Real Potosí | - | Cerro Porteño | 0:1 | ||||
| Round of 16 | 23/09/2016 | Santa Fe | - | Cerro Porteño | 2:0 | ||||
| Round of 16 | 30/09/2016 | Cerro Porteño | - | Santa Fe | 4:1 |  |
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| Quarter-finals | 19/10/2016 | Independiente Medellín | - | Cerro Porteño | 0:0 | ||||
| Quarter-finals | 26/10/2016 | Cerro Porteño | - | Independiente Medellín | 2:0 | ||||
| Semi-finals | 01/11/2016 | Cerro Porteño | - | Atlético Nacional | 1:1 | |
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| Semi-finals | 25/11/2016 | Atlético Nacional | - | Cerro Porteño | 0:0 | |
Uruguay
Argentina 