| 2. Round | 16/07/2016 | Cerro Porteño | - | Club Nacional | 1:1 | ||||
| 3. Round | 20/07/2016 | Libertad | - | Cerro Porteño | 1:1 | ||||
| 4. Round | 23/07/2016 | Cerro Porteño | - | General Díaz | 2:3 |  |
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| 8. Round | 21/08/2016 | Cerro Porteño | - | General Caballero ZC | 1:2 |  |
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| 9. Round | 29/08/2016 | River Plate | - | Cerro Porteño | 2:3 | ||||
| 10. Round | 10/09/2016 | Cerro Porteño | - | Deportivo Capiatá | 2:1 | ||||
| 13. Round | 02/10/2016 | Club Nacional | - | Cerro Porteño | 1:6 | ||||
| 14. Round | 15/10/2016 | Cerro Porteño | - | Libertad | 2:1 | ||||
| 15. Round | 22/10/2016 | General Díaz | - | Cerro Porteño | 1:1 | ||||
| 17. Round | 06/11/2016 | Club Olimpia | - | Cerro Porteño | 4:2 | |
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| 18. Round | 19/11/2016 | Cerro Porteño | - | Club Rubio Ñu | 1:0 | |
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| 19. Round | 27/11/2016 | General Caballero ZC | - | Cerro Porteño | 1:1 | ||||
| 20. Round | 02/12/2016 | Cerro Porteño | - | River Plate | 4:0 | ||||
| 12. Round | 06/12/2016 | Cerro Porteño | - | Sol de América | 2:2 | |
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| 22. Round | 17/12/2016 | Cerro Porteño | - | Sportivo Luqueño | 4:1 |
Uruguay
Argentina 