| 1. Round | 11/01/2022 | CF América [Women] | - | Atlas Guadalajara [Women] | 1:1 |  |
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| 2. Round | 17/01/2022 | Atlas Guadalajara [Women] | - | Mazatlán FC [Women] | 1:1 | ||||
| 3. Round | 22/01/2022 | Atlas Guadalajara [Women] | - | Santos Laguna [Women] | 1:0 | ||||
| 4. Round | 29/01/2022 | UANL Tigres [Women] | - | Atlas Guadalajara [Women] | 5:1 | ||||
| 5. Round | 31/01/2022 | Atlas Guadalajara [Women] | - | Puebla FC [Women] | 1:0 | ||||
| 6. Round | 07/02/2022 | Club Necaxa [Women] | - | Atlas Guadalajara [Women] | 1:1 | |
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| 7. Round | 12/02/2022 | Atlas Guadalajara [Women] | - | Atlético San Luis [Women] | 1:1 | ||||
| 8. Round | 01/03/2022 | CF Monterrey [Women] | - | Atlas Guadalajara [Women] | 5:1 | ||||
| 9. Round | 05/03/2022 | Atlas Guadalajara [Women] | - | Club Tijuana [Women] | 6:1 | ||||
| 11. Round | 18/03/2022 | Pumas UNAM [Women] | - | Atlas Guadalajara [Women] | 0:0 | ||||
| 12. Round | 21/03/2022 | Atlas Guadalajara [Women] | - | FC Juárez [Women] | 2:1 | |
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| 13. Round | 26/03/2022 | Cruz Azul [Women] | - | Atlas Guadalajara [Women] | 2:1 |
Mexico