| 1. Round | 20/03/2016 | Los Angeles Galaxy | - | San Jose Earthquakes | 3:1 |  |
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| 2. Round | 03/04/2016 | San Jose Earthquakes | - | D.C. United | 1:1 | |
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| 2. Round | 10/04/2016 | FC Dallas | - | San Jose Earthquakes | 2:2 | ||||
| 2. Round | 14/04/2016 | San Jose Earthquakes | - | New York RB | 2:0 | ||||
| 2. Round | 17/04/2016 | Portland Timbers | - | San Jose Earthquakes | 3:1 | ||||
| 2. Round | 24/04/2016 | San Jose Earthquakes | - | Sporting Kansas City | 1:0 | ||||
| 5. Round | 01/08/2016 | Houston Dynamo | - | San Jose Earthquakes | 1:1 | ||||
| 6. Round | 28/08/2016 | Columbus Crew | - | San Jose Earthquakes | 2:0 | ||||
| 7. Round | 11/09/2016 | San Jose Earthquakes | - | Seattle Sounders | 1:1 | ||||
| 7. Round | 18/09/2016 | Colorado Rapids | - | San Jose Earthquakes | 0:0 | ||||
| 7. Round | 29/09/2016 | Impact de Montréal | - | San Jose Earthquakes | 3:1 |
Argentina