1. Round | 25/07/2010 | Club San Luis | - | CF Monterrey | 1:1 | ||||
2. Round | 01/08/2010 | Puebla FC | - | Club San Luis | 2:1 | ||||
3. Round | 08/08/2010 | Club San Luis | - | Deportivo Guadalajara | 0:1 | ||||
4. Round | 15/08/2010 | Club San Luis | - | Monarcas Morelia | 1:0 | ||||
5. Round | 21/08/2010 | Estudiantes Tecos | - | Club San Luis | 3:2 | ||||
6. Round | 29/08/2010 | Club San Luis | - | Atlante | 2:1 | ||||
7. Round | 12/09/2010 | Pumas UNAM | - | Club San Luis | 0:1 | ||||
8. Round | 19/09/2010 | Club San Luis | - | CF Pachuca | 1:0 | ||||
9. Round | 25/09/2010 | Jaguares Chiapas | - | Club San Luis | 2:1 | ||||
10. Round | 03/10/2010 | Club San Luis | - | UANL Tigres | 1:0 | ||||
11. Round | 10/10/2010 | Atlas Guadalajara | - | Club San Luis | 2:1 | ||||
13. Round | 23/10/2010 | Club Necaxa | - | Club San Luis | 0:2 | ||||
14. Round | 29/10/2010 | Club San Luis | - | CF América | 1:2 | ||||
15. Round | 31/10/2010 | Deportivo Toluca | - | Club San Luis | 1:2 | ||||
16. Round | 06/11/2010 | Club San Luis | - | Santos Laguna | 1:1 | ||||
17. Round | 13/11/2010 | Cruz Azul | - | Club San Luis | 1:0 |