| 4. Round | 13/09/2021 | Balıkesirspor | - | Tuzlaspor | 0:1 | ||||
| 6. Round | 19/09/2021 | Tuzlaspor | - | Bursaspor | 0:0 | ||||
| 7. Round | 24/09/2021 | Kocaelispor | - | Tuzlaspor | 1:0 | ||||
| 9. Round | 18/10/2021 | İstanbulspor AŞ | - | Tuzlaspor | 1:0 | ||||
| 10. Round | 23/10/2021 | Tuzlaspor | - | Bandırmaspor | 0:3 | ||||
| 12. Round | 05/11/2021 | Tuzlaspor | - | Denizlispor | 3:0 |  |
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| 13. Round | 20/11/2021 | Gençlerbirliği | - | Tuzlaspor | 0:1 | ||||
| 15. Round | 04/12/2021 | Adanaspor | - | Tuzlaspor | 1:1 | ||||
| 17. Round | 15/12/2021 | Eyüpspor | - | Tuzlaspor | 2:0 |
Turkey