| Group A | 08/09/2022 | ACF Fiorentina | - | FK RFS | 1:1 |  |
|||
| Group A | 15/09/2022 | İstanbul Başakşehir | - | ACF Fiorentina | 3:0 | ||||
| Group A | 13/10/2022 | ACF Fiorentina | - | Heart of Midlothian | 5:1 | |
|||
| Group A | 27/10/2022 | ACF Fiorentina | - | İstanbul Başakşehir | 2:1 | ||||
| Group A | 03/11/2022 | FK RFS | - | ACF Fiorentina | 0:3 | |
|||
| Play-offs | 16/02/2023 | Sporting Braga | - | ACF Fiorentina | 0:4 | ||||
| Round of 16 | 09/03/2023 | ACF Fiorentina | - | Sivasspor | 1:0 | |
|||
| Quarter-finals | 13/04/2023 | Lech Poznań | - | ACF Fiorentina | 1:4 | ||||
| Quarter-finals | 20/04/2023 | ACF Fiorentina | - | Lech Poznań | 2:3 | ||||
| Semi-finals | 11/05/2023 | ACF Fiorentina | - | FC Basel 1893 | 1:2 | ||||
| Semi-finals | 18/05/2023 | FC Basel 1893 | - | ACF Fiorentina | 1:3 aet | |
 |
||
| Final | 07/06/2023 | ACF Fiorentina | - | West Ham United | 1:2 |
Czech Republic