| 1. Round | 04/04/2021 | Deportes Iquique | - | Coquimbo Unido | 2:3 | ||||
| 3. Round | 25/04/2021 | Deportes Iquique | - | San Marcos | 1:2 | ||||
| 4. Round | 03/05/2021 | Barnechea | - | Deportes Iquique | 3:1 | ||||
| 6. Round | 18/05/2021 | Deportes Copiapó | - | Deportes Iquique | 0:2 | ||||
| 7. Round | 23/05/2021 | Deportes Iquique | - | CD Magallanes | 1:1 | ||||
| 8. Round | 30/05/2021 | Santa Cruz | - | Deportes Iquique | 1:3 |  |
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| 9. Round | 06/06/2021 | Deportes Iquique | - | Universidad de Concepción | 5:1 | ||||
| 10. Round | 09/07/2021 | Cobreloa | - | Deportes Iquique | 3:2 | ||||
| 18. Round | 02/09/2021 | San Marcos | - | Deportes Iquique | 4:2 | ||||
| 19. Round | 05/09/2021 | Deportes Iquique | - | Barnechea | 4:2 | ||||
| 23. Round | 03/10/2021 | Deportes Iquique | - | Santa Cruz | 6:1 | ||||
| 25. Round | 13/10/2021 | Deportes Iquique | - | Cobreloa | 1:0 | ||||
| 26. Round | 20/10/2021 | Deportes Iquique | - | Unión San Felipe | 1:0 |  |
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| 27. Round | 25/10/2021 | Santiago Morning | - | Deportes Iquique | 1:0 | |
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| 28. Round | 01/11/2021 | Deportes Iquique | - | Rangers | 2:2 | ||||
| 29. Round | 06/11/2021 | Deportes Temuco | - | Deportes Iquique | 2:1 | ||||
| 30. Round | 13/11/2021 | Deportes Iquique | - | Puerto Montt | 4:2 |
Argentina