| 4. Round | 02/09/2018 | Adana Demirspor | - | İstanbulspor AŞ | 2:2 |  |
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| 6. Round | 22/09/2018 | Hatayspor | - | İstanbulspor AŞ | 1:0 | |
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| 7. Round | 30/09/2018 | İstanbulspor AŞ | - | Boluspor | 1:3 | ||||
| 8. Round | 06/10/2018 | Altınordu FK | - | İstanbulspor AŞ | 1:1 | ||||
| 9. Round | 21/10/2018 | İstanbulspor AŞ | - | Giresunspor | 3:1 | ||||
| 10. Round | 28/10/2018 | Eskişehirspor | - | İstanbulspor AŞ | 1:0 | ||||
| 11. Round | 05/11/2018 | İstanbulspor AŞ | - | Balıkesirspor | 3:0 | ||||
| 12. Round | 11/11/2018 | Osmanlıspor FK | - | İstanbulspor AŞ | 1:0 | ||||
| 13. Round | 24/11/2018 | İstanbulspor AŞ | - | Gençlerbirliği | 2:0 | ||||
| 19. Round | 26/01/2019 | İstanbulspor AŞ | - | Gazişehir Gaziantep FK | 2:2 | ||||
| 20. Round | 04/02/2019 | Altay Izmir | - | İstanbulspor AŞ | 1:1 | ||||
| 21. Round | 10/02/2019 | İstanbulspor AŞ | - | Adana Demirspor | 2:0 | ||||
| 23. Round | 22/02/2019 | İstanbulspor AŞ | - | Hatayspor | 0:3 | ||||
| 24. Round | 03/03/2019 | Boluspor | - | İstanbulspor AŞ | 2:1 | ||||
| 28. Round | 06/04/2019 | Balıkesirspor | - | İstanbulspor AŞ | 1:5 | ||||
| 32. Round | 04/05/2019 | İstanbulspor AŞ | - | Karabükspor | 1:0 |
Turkey