| 11. Round | 07/11/2021 | West Ham United | - | Liverpool FC | 3:2 | ||||
| 13. Round | 28/11/2021 | Manchester City | - | West Ham United | 2:1 | ||||
| 14. Round | 01/12/2021 | West Ham United | - | Brighton & Hove Albion | 1:1 | ||||
| 15. Round | 04/12/2021 | West Ham United | - | Chelsea FC | 3:2 |  |
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| 16. Round | 12/12/2021 | Burnley FC | - | West Ham United | 0:0 | ||||
| 17. Round | 15/12/2021 | Arsenal FC | - | West Ham United | 2:0 | ||||
| 19. Round | 26/12/2021 | West Ham United | - | Southampton FC | 2:3 | ||||
| 20. Round | 28/12/2021 | Watford FC | - | West Ham United | 1:4 | ||||
| 21. Round | 01/01/2022 | Crystal Palace | - | West Ham United | 2:3 |  |
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| 18. Round | 12/01/2022 | West Ham United | - | Norwich City | 2:0 | ||||
| 22. Round | 16/01/2022 | West Ham United | - | Leeds United | 2:3 | ||||
| 30. Round | 20/03/2022 | Tottenham Hotspur | - | West Ham United | 3:1 | ||||
| 34. Round | 24/04/2022 | Chelsea FC | - | West Ham United | 1:0 |
France
