| 1. Round | 26/02/2022 | Los Angeles FC | - | Colorado Rapids | 3:0 | ||||
| 2. Round | 05/03/2022 | Colorado Rapids | - | Atlanta United FC | 3:0 |  |
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| 2. Round | 13/03/2022 | Colorado Rapids | - | Sporting Kansas City | 2:0 | ||||
| 2. Round | 20/03/2022 | Houston Dynamo | - | Colorado Rapids | 1:1 | |
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| 3. Round | 03/04/2022 | Colorado Rapids | - | Real Salt Lake | 1:1 | ||||
| 3. Round | 10/04/2022 | FC Dallas | - | Colorado Rapids | 3:1 | ||||
| 3. Round | 17/04/2022 | Minnesota United FC | - | Colorado Rapids | 3:1 | ||||
| 3. Round | 24/04/2022 | Colorado Rapids | - | Charlotte FC | 0:0 | ||||
| 4. Round | 01/05/2022 | Colorado Rapids | - | Portland Timbers | 2:0 | |
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| 4. Round | 08/05/2022 | San Jose Earthquakes | - | Colorado Rapids | 1:0 | ||||
| 4. Round | 14/05/2022 | Colorado Rapids | - | Los Angeles FC | 2:0 | ||||
| 4. Round | 19/05/2022 | Sporting Kansas City | - | Colorado Rapids | 2:1 |  |
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| 4. Round | 29/05/2022 | Colorado Rapids | - | Nashville SC | 1:3 | ||||
| 5. Round | 19/06/2022 | New York City FC | - | Colorado Rapids | 1:1 | ||||
| 5. Round | 26/06/2022 | Portland Timbers | - | Colorado Rapids | 3:0 | ||||
| 6. Round | 05/07/2022 | Colorado Rapids | - | Austin FC | 2:3 |
USA