| 1. Round | 12/02/2022 | Atlético San Miguel | - | Fénix | 0:2 | ||||
| 3. Round | 26/02/2022 | Armenio | - | Atlético San Miguel | 1:1 | ||||
| 4. Round | 05/03/2022 | Atlético San Miguel | - | Dock Sud | 0:1 |  |
|||
| 5. Round | 12/03/2022 | UAI Urquiza | - | Atlético San Miguel | 2:0 | ||||
| 6. Round | 20/03/2022 | Atlético San Miguel | - | Villa San Carlos | 2:1 | ||||
| 7. Round | 26/03/2022 | Defensores Unidos de Zárate | - | Atlético San Miguel | 2:1 | ||||
| 9. Round | 09/04/2022 | Deportivo Merlo | - | Atlético San Miguel | 2:0 | ||||
| 10. Round | 16/04/2022 | Atlético San Miguel | - | Colegiales de Munro | 0:1 | ||||
| 11. Round | 24/04/2022 | Acassuso | - | Atlético San Miguel | 2:1 |
Argentina