| 2. Round | 26/01/2020 | Guaraní | - | Cerro Porteño | 1:0 | ||||
| 3. Round | 01/02/2020 | 12 de Octubre de Itauguá | - | Guaraní | 1:3 | ||||
| 4. Round | 08/02/2020 | Guaraní | - | Club Olimpia | 0:3 dec. | ||||
| 5. Round | 16/02/2020 | Club Nacional | - | Guaraní | 1:2 | ||||
| 7. Round | 01/03/2020 | Sportivo Luqueño | - | Guaraní | 0:3 | ||||
| 8. Round | 07/03/2020 | Guaraní | - | Sol de América | 1:1 |  |
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| 9. Round | 23/07/2020 | Guaireña FC | - | Guaraní | 1:1 | ||||
| 10. Round | 27/07/2020 | Guaraní | - | General Díaz | 0:0 | ||||
| 11. Round | 01/08/2020 | Libertad | - | Guaraní | 1:3 |  |
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| 6. Round | 05/08/2020 | Guaraní | - | River Plate | 3:0 | |
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| 12. Round | 09/08/2020 | San Lorenzo | - | Guaraní | 1:1 | ||||
| 13. Round | 13/08/2020 | Cerro Porteño | - | Guaraní | 1:0 | ||||
| 14. Round | 16/08/2020 | Guaraní | - | 12 de Octubre de Itauguá | 2:2 | ||||
| 15. Round | 21/08/2020 | Club Olimpia | - | Guaraní | 1:2 | |
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| 16. Round | 25/08/2020 | Guaraní | - | Club Nacional | 1:0 | ||||
| 17. Round | 29/08/2020 | River Plate | - | Guaraní | 1:0 | ||||
| 18. Round | 05/09/2020 | Guaraní | - | Sportivo Luqueño | 3:0 | ||||
| 19. Round | 12/09/2020 | Sol de América | - | Guaraní | 1:2 | ||||
| 20. Round | 20/09/2020 | Guaraní | - | Guaireña FC | 0:0 | ||||
| 22. Round | 04/10/2020 | Guaraní | - | Libertad | 1:1 |
Argentina