| 14. Round | 03/12/2021 | Brighton & Hove Albion U23 | - | Liverpool FC U23 | 3:0 |  |
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| 15. Round | 17/12/2021 | Manchester City U23 | - | Brighton & Hove Albion U23 | 3:1 | ||||
| 16. Round | 07/01/2022 | Brighton & Hove Albion U23 | - | Arsenal FC U23 | 1:1 | ||||
| 17. Round | 17/01/2022 | Leicester City U23 | - | Brighton & Hove Albion U23 | 2:1 | ||||
| 19. Round | 04/02/2022 | Blackburn Rovers U23 | - | Brighton & Hove Albion U23 | 6:0 | ||||
| 22. Round | 11/03/2022 | Brighton & Hove Albion U23 | - | Everton FC U23 | 4:2 | ||||
| 23. Round | 18/03/2022 | West Ham United U23 | - | Brighton & Hove Albion U23 | 3:2 | ||||
| 20. Round | 15/04/2022 | Brighton & Hove Albion U23 | - | Leeds United U23 | 1:0 |
Northern Ireland