| 2. Round | 23/08/2021 | Trabzonspor | - | Sivasspor | 2:1 | ||||
| 3. Round | 29/08/2021 | Giresunspor | - | Trabzonspor | 0:1 | ||||
| 4. Round | 12/09/2021 | Trabzonspor | - | Galatasaray | 2:2 | ||||
| 15. Round | 04/12/2021 | Trabzonspor | - | Adana Demirspor | 2:0 | ||||
| 16. Round | 11/12/2021 | Antalyaspor | - | Trabzonspor | 2:1 |  |
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| 17. Round | 18/12/2021 | Trabzonspor | - | Hatayspor | 2:0 | ||||
| 18. Round | 21/12/2021 | Altay Izmir | - | Trabzonspor | 1:2 | ||||
| 19. Round | 25/12/2021 | Trabzonspor | - | İstanbul Başakşehir | 0:0 | ||||
| 20. Round | 07/01/2022 | Trabzonspor | - | Yeni Malatyaspor | 1:0 | ||||
| 21. Round | 15/01/2022 | Sivasspor | - | Trabzonspor | 1:1 | ||||
| 27. Round | 25/02/2022 | Trabzonspor | - | Kayserispor | 3:2 | ||||
| 28. Round | 06/03/2022 | Fenerbahçe | - | Trabzonspor | 1:1 | ||||
| 30. Round | 18/03/2022 | Çaykur Rizespor | - | Trabzonspor | 3:2 | ||||
| 32. Round | 09/04/2022 | Gaziantep FK | - | Trabzonspor | 0:0 | ||||
| 33. Round | 15/04/2022 | Trabzonspor | - | Fatih Karagümrük | 1:1 | ||||
| 35. Round | 30/04/2022 | Trabzonspor | - | Antalyaspor | 2:2 | ||||
| 37. Round | 15/05/2022 | Trabzonspor | - | Altay Izmir | 2:1 | ||||
| 38. Round | 22/05/2022 | İstanbul Başakşehir | - | Trabzonspor | 3:1 |
France