| 10. Round | 03/09/2021 | Colón de Santa Fe II | - | Newell's Old Boys II | 1:1 | ||||
| 11. Round | 10/09/2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Round | 17/09/2021 | Lanús II | - | Newell's Old Boys II | 0:2 | ||||
| 13. Round | 24/09/2021 | Newell's Old Boys II | - | Huracán II | 2:0 | ||||
| 16. Round | 14/10/2021 | Gimnasia de La Plata II | - | Newell's Old Boys II | 1:1 | ||||
| 17. Round | 18/10/2021 | Newell's Old Boys II | - | Aldosivi II | 1:0 | ||||
| 24. Round | 06/12/2021 | Newell's Old Boys II | - | Banfield II | 2:0 |
Argentina