| 2. Round | 15/02/2022 | Argentinos Juniors II | - | Newell's Old Boys II | 1:1 | ||||
| 3. Round | 19/02/2022 | Newell's Old Boys II | - | River Plate II | 1:2 | ||||
| 5. Round | 04/03/2022 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 | ||||
| 7. Round | 18/03/2022 | Rosario Central II | - | Newell's Old Boys II | 2:1 | ||||
| 8. Round | 04/04/2022 | Newell's Old Boys II | - | Platense II | 1:2 | ||||
| 9. Round | 08/04/2022 | Unión de Santa Fe II | - | Newell's Old Boys II | 1:1 | ||||
| 11. Round | 19/04/2022 | Newell's Old Boys II | - | Banfield II | 1:0 |
Argentina