| 1. Round | 12/02/2022 | Atlético San Miguel | - | Fénix | 0:2 | ||||
| 3. Round | 26/02/2022 | Armenio | - | Atlético San Miguel | 1:1 |  |
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| 4. Round | 05/03/2022 | Atlético San Miguel | - | Dock Sud | 0:1 | ||||
| 9. Round | 09/04/2022 | Deportivo Merlo | - | Atlético San Miguel | 2:0 | ||||
| 10. Round | 16/04/2022 | Atlético San Miguel | - | Colegiales de Munro | 0:1 | ||||
| 12. Round | 02/05/2022 | Atlético San Miguel | - | Argentino de Quilmes | 1:0 | ||||
| 14. Round | 14/05/2022 | Atlético San Miguel | - | Cañuelas | 1:1 | ||||
| 15. Round | 22/05/2022 | Comunicaciones de Buenos Aires | - | Atlético San Miguel | 2:3 | ||||
| 16. Round | 28/05/2022 | Atlético San Miguel | - | CA Los Andes | 1:1 | |
Argentina