| 1. Round | 16/08/2021 | Yeni Malatyaspor | - | Trabzonspor | 1:5 | ||||
| 2. Round | 22/08/2021 | Göztepe | - | Yeni Malatyaspor | 0:1 | ||||
| 22. Round | 20/01/2022 | Gaziantep FK | - | Yeni Malatyaspor | 0:0 | ||||
| 26. Round | 19/02/2022 | Yeni Malatyaspor | - | Antalyaspor | 1:2 |  |
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| 27. Round | 27/02/2022 | Hatayspor | - | Yeni Malatyaspor | 5:2 | ||||
| 28. Round | 04/03/2022 | Yeni Malatyaspor | - | Adana Demirspor | 1:0 | ||||
| 30. Round | 19/03/2022 | Yeni Malatyaspor | - | Kasımpaşa SK | 0:2 | ||||
| 33. Round | 18/04/2022 | Galatasaray | - | Yeni Malatyaspor | 2:0 | ||||
| 34. Round | 24/04/2022 | Yeni Malatyaspor | - | Konyaspor | 2:3 | ||||
| 35. Round | 01/05/2022 | Alanyaspor | - | Yeni Malatyaspor | 2:1 |  |
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| 36. Round | 08/05/2022 | Yeni Malatyaspor | - | Çaykur Rizespor | 1:3 | |
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| 37. Round | 14/05/2022 | Kayserispor | - | Yeni Malatyaspor | 3:0 | |
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| 38. Round | 21/05/2022 | Yeni Malatyaspor | - | Fenerbahçe | 0:5 |
Turkey