| 1. Round | 31/07/2021 | Peterhead FC | - | Alloa Athletic | 2:0 | ||||
| 3. Round | 14/08/2021 | Clyde FC | - | Alloa Athletic | 2:1 | ||||
| 4. Round | 21/08/2021 | Alloa Athletic | - | Queen's Park FC | 1:1 | ||||
| 6. Round | 11/09/2021 | Alloa Athletic | - | Falkirk FC | 2:0 | ||||
| 7. Round | 18/09/2021 | Montrose FC | - | Alloa Athletic | 0:2 | ||||
| 8. Round | 25/09/2021 | Dumbarton FC | - | Alloa Athletic | 1:1 | ||||
| 19. Round | 26/12/2021 | Airdrieonians FC | - | Alloa Athletic | 3:1 | ||||
| 21. Round | 08/01/2022 | Montrose FC | - | Alloa Athletic | 1:1 | ||||
| 23. Round | 29/01/2022 | Clyde FC | - | Alloa Athletic | 2:1 | ||||
| 20. Round | 08/02/2022 | Alloa Athletic | - | Falkirk FC | 0:3 | ||||
| 25. Round | 12/02/2022 | Alloa Athletic | - | East Fife FC | 1:3 | ||||
| 26. Round | 19/02/2022 | Dumbarton FC | - | Alloa Athletic | 1:2 | ||||
| 28. Round | 05/03/2022 | Alloa Athletic | - | Airdrieonians FC | 0:2 | ||||
| 29. Round | 12/03/2022 | Queen's Park FC | - | Alloa Athletic | 1:1 | ||||
| 31. Round | 26/03/2022 | East Fife FC | - | Alloa Athletic | 0:3 | ||||
| 32. Round | 02/04/2022 | Alloa Athletic | - | Dumbarton FC | 2:3 | ||||
| 33. Round | 09/04/2022 | Alloa Athletic | - | Clyde FC | 1:0 | ||||
| 36. Round | 30/04/2022 | Alloa Athletic | - | Montrose FC | 4:1 |
Scotland