| 1. Round | 09/01/2022 | Deportivo Guadalajara [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 3. Round | 21/01/2022 | Mazatlán FC [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 4. Round | 06/02/2022 | UANL Tigres [U20] | - | Mazatlán FC [U20] | 3:2 | ||||
| 5. Round | 11/02/2022 | Mazatlán FC [U20] | - | Club Tijuana [U20] | 0:2 | ||||
| 2. Round | 16/02/2022 | Mazatlán FC [U20] | - | CF América [U20] | 2:1 | ||||
| 6. Round | 20/02/2022 | Gallos Blancos [U20] | - | Mazatlán FC [U20] | 0:0 | ||||
| 8. Round | 01/03/2022 | Mazatlán FC [U20] | - | Club Necaxa [U20] | 1:3 | ||||
| 10. Round | 11/03/2022 | CF Monterrey [U20] | - | Mazatlán FC [U20] | 2:3 |  |
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| 11. Round | 20/03/2022 | Mazatlán FC [U20] | - | Club León [U20] | 1:0 | ||||
| 9. Round | 27/03/2022 | Pumas UNAM [U20] | - | Mazatlán FC [U20] | 3:0 | ||||
| 12. Round | 01/04/2022 | Atlético San Luis [U20] | - | Mazatlán FC [U20] | 1:2 | ||||
| 15. Round | 19/04/2022 | Mazatlán FC [U20] | - | Santos Laguna [U20] | 1:2 | ||||
| 16. Round | 22/04/2022 | FC Juárez [U20] | - | Mazatlán FC [U20] | 3:0 | ||||
| 17. Round | 29/04/2022 | Mazatlán FC [U20] | - | Puebla FC [U20] | 4:1 |
Mexico