| 1. Round | 26/07/2020 | Pumas UNAM | - | Gallos Blancos | 3:2 | ||||
| 2. Round | 04/08/2020 | Atlas Guadalajara | - | Pumas UNAM | 1:2 | ||||
| 3. Round | 09/08/2020 | Pumas UNAM | - | FC Juárez | 1:1 |  |
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| 4. Round | 13/08/2020 | Pumas UNAM | - | CF Monterrey | 1:1 | ||||
| 5. Round | 16/08/2020 | Mazatlán FC | - | Pumas UNAM | 0:0 | ||||
| 6. Round | 23/08/2020 | UANL Tigres | - | Pumas UNAM | 1:1 | |
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| 7. Round | 30/08/2020 | Pumas UNAM | - | Club Tijuana | 3:0 | |
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| 8. Round | 05/09/2020 | Pumas UNAM | - | Puebla FC | 4:1 | |
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| 9. Round | 10/09/2020 | Santos Laguna | - | Pumas UNAM | 1:2 | ||||
| 10. Round | 13/09/2020 | Pumas UNAM | - | Atlético San Luis | 3:0 | ||||
| 11. Round | 22/09/2020 | Club León | - | Pumas UNAM | 2:0 | ||||
| 12. Round | 27/09/2020 | Pumas UNAM | - | Club Necaxa | 1:1 | ||||
| 14. Round | 18/10/2020 | Pumas UNAM | - | Deportivo Toluca | 1:0 | ||||
| 15. Round | 27/10/2020 | CF Pachuca | - | Pumas UNAM | 1:1 | ||||
| 16. Round | 01/11/2020 | Pumas UNAM | - | Deportivo Guadalajara | 2:2 | |
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| 17. Round | 08/11/2020 | Cruz Azul | - | Pumas UNAM | 1:2 |
Paraguay