| Round of 32 | 24/03/2021 | Boca Juniors | - | Defensores de Belgrano | 3:0 | ||||
| Round of 16 | 04/08/2021 | Boca Juniors | - | River Plate | 4:1 pso | ||||
| Quarter-finals | 23/09/2021 | Boca Juniors | - | Patronato de Paraná | 4:2 pso | ||||
| Semi-finals | 04/11/2021 | Boca Juniors | - | Argentinos Juniors | 1:0 |  |
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| Final | 09/12/2021 | Talleres de Córdoba | - | Boca Juniors | 4:5 pso |
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