| 1. Round | 05/09/1980 | Sevilla FC | - | UD Salamanca | 1:0 |  |
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| 2. Round | 13/09/1980 | Real Zaragoza | - | Sevilla FC | 2:0 | ||||
| 3. Round | 20/09/1980 | Sevilla FC | - | Real Madrid | 2:0 |  |
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| 4. Round | 27/09/1980 | Real Valladolid | - | Sevilla FC | 2:3 | |
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| 5. Round | 05/10/1980 | Sevilla FC | - | AD Almería | 1:0 | |
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| 6. Round | 11/10/1980 | Athletic Club | - | Sevilla FC | 3:0 | ||||
| 7. Round | 19/10/1980 | Atlético Madrid | - | Sevilla FC | 2:0 | ||||
| 8. Round | 26/10/1980 | Sevilla FC | - | Real Murcia | 1:0 | |
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| 9. Round | 01/11/1980 | Espanyol Barcelona | - | Sevilla FC | 2:2 | ||||
| 10. Round | 08/11/1980 | Sevilla FC | - | Sporting Gijón | 3:2 | |
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| 11. Round | 15/11/1980 | Valencia CF | - | Sevilla FC | 2:0 | |
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| 13. Round | 28/11/1980 | UD Las Palmas | - | Sevilla FC | 1:2 | |
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| 15. Round | 13/12/1980 | Real Betis | - | Sevilla FC | 2:0 | ||||
| 16. Round | 20/12/1980 | Sevilla FC | - | Hércules CF | 0:0 | ||||
| 18. Round | 03/01/1981 | UD Salamanca | - | Sevilla FC | 0:0 | ||||
| 19. Round | 10/01/1981 | Sevilla FC | - | Real Zaragoza | 0:0 | ||||
| 20. Round | 17/01/1981 | Real Madrid | - | Sevilla FC | 3:2 | ||||
| 23. Round | 07/02/1981 | Sevilla FC | - | Athletic Club | 2:0 | ||||
| 24. Round | 14/02/1981 | Sevilla FC | - | Atlético Madrid | 1:1 |
Argentina