| 11. Round | 25/09/2021 | Santa Fe | - | Envigado FC | 3:1 | ||||
| 12. Round | 02/10/2021 | Deportes Tolima | - | Santa Fe | 0:0 | ||||
| 13. Round | 12/10/2021 | Patriotas FC | - | Santa Fe | 0:1 |  |
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| 14. Round | 18/10/2021 | Santa Fe | - | Millonarios | 0:2 | ||||
| 15. Round | 25/10/2021 | Atlético Huila | - | Santa Fe | 1:2 | ||||
| 16. Round | 28/10/2021 | Santa Fe | - | Jaguares de Córdoba | 3:1 |  |
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| 17. Round | 02/11/2021 | Deportes Quindío | - | Santa Fe | 1:1 | |
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| 18. Round | 07/11/2021 | Santa Fe | - | Atlético Junior | 1:1 | ||||
| 19. Round | 16/11/2021 | Once Caldas | - | Santa Fe | 2:1 |
Colombia
France 
