| 4. Round | 01/02/2021 | CF Pachuca [Women] | - | Deportivo Guadalajara [Women] | 1:0 | ||||
| 5. Round | 05/02/2021 | Gallos Blancos [Women] | - | Deportivo Guadalajara [Women] | 3:3 | ||||
| 6. Round | 08/02/2021 | Deportivo Guadalajara [Women] | - | Atlético San Luis [Women] | 3:0 | ||||
| 7. Round | 12/02/2021 | Club Necaxa [Women] | - | Deportivo Guadalajara [Women] | 0:2 | ||||
| 10. Round | 12/03/2021 | Deportivo Guadalajara [Women] | - | Deportivo Toluca [Women] | 1:1 | ||||
| 12. Round | 21/03/2021 | Deportivo Guadalajara [Women] | - | Puebla FC [Women] | 3:0 | ||||
| 15. Round | 16/04/2021 | Cruz Azul [Women] | - | Deportivo Guadalajara [Women] | 0:1 |
Mexico