| 1. Round | 08/01/2022 | CF Monterrey [U20] | - | Gallos Blancos [U20] | 0:0 | ||||
| 3. Round | 22/01/2022 | CF Monterrey [U20] | - | Cruz Azul [U20] | 2:2 | ||||
| 4. Round | 06/02/2022 | Deportivo Toluca [U20] | - | CF Monterrey [U20] | 3:0 | ||||
| 5. Round | 12/02/2022 | CF Monterrey [U20] | - | FC Juárez [U20] | 1:0 | ||||
| 7. Round | 26/02/2022 | CF Monterrey [U20] | - | Atlético San Luis [U20] | 1:3 | ||||
| 8. Round | 01/03/2022 | Club León [U20] | - | CF Monterrey [U20] | 1:2 | ||||
| 9. Round | 05/03/2022 | CF Monterrey [U20] | - | CF América [U20] | 3:2 | ||||
| 10. Round | 11/03/2022 | CF Monterrey [U20] | - | Mazatlán FC [U20] | 2:3 |
Mexico