| 1. Round | 25/06/2022 | Atlético San Luis [] | - | CF Monterrey [] | 0:5 | ||||
| 3. Round | 09/07/2022 | Mazatlán FC [] | - | Atlético San Luis [] | 1:2 | ||||
| 4. Round | 16/07/2022 | Atlético San Luis [] | - | Santos Laguna [] | 2:7 | ||||
| 5. Round | 23/07/2022 | Atlas Guadalajara [] | - | Atlético San Luis [] | 8:1 | ||||
| 6. Round | 30/07/2022 | Atlético San Luis [] | - | UANL Tigres [] | 1:4 |  |
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| 7. Round | 05/08/2022 | Club León [] | - | Atlético San Luis [] | 2:0 | |
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| 8. Round | 13/08/2022 | Atlético San Luis [] | - | Deportivo Guadalajara [] | 2:1 | ||||
| 9. Round | 20/08/2022 | Club Tijuana [] | - | Atlético San Luis [] | 6:3 | ||||
| 10. Round | 27/08/2022 | CF Monterrey [] | - | Atlético San Luis [] | 5:1 | ||||
| 11. Round | 03/09/2022 | Atlético San Luis [] | - | Club Tijuana [] | 0:2 | |
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| 12. Round | 11/09/2022 | Deportivo Guadalajara [] | - | Atlético San Luis [] | 3:1 | ||||
| 13. Round | 18/09/2022 | Atlético San Luis [] | - | Club León [] | 0:4 | ||||
| 16. Round | 08/10/2022 | Santos Laguna [] | - | Atlético San Luis [] | 4:0 |
Mexico