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| 03/09/2022 | 15:00 | CF Pachuca | - | Cruz Azul | 1:1 (0:1) | |
| 16:00 | Mazatlán FC | - | Deportivo Guadalajara | 2:8 (0:3) | ||
| 17:30 | Club Necaxa | - | Deportivo Toluca | 2:0 (1:0) | ||
| 17:30 | Pumas UNAM | - | Gallos Blancos | 3:0 (3:0) | ||
| 17:30 | Atlas Guadalajara | - | UANL Tigres | 1:2 (0:1) | ||
| 17:30 | Santos Laguna | - | Club León | 2:0 (2:0) | ||
| 17:45 | Atlético San Luis | - | Club Tijuana | 0:2 (0:0) | ||
| 18:15 | FC Juárez | - | Puebla FC | 2:1 (2:1) |
| » Tables | Home | Away | First round | Second round |
| 1 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 10 | 9 | 1 | 0 | 26:10 | 16 | 28 |
| 2 |
|
Club Necaxa | 10 | 6 | 1 | 3 | 18:5 | 13 | 19 |
| 3 |
|
Deportivo Toluca | 9 | 4 | 3 | 2 | 17:14 | 3 | 15 |
| 4 |
|
CF Pachuca | 10 | 3 | 5 | 2 | 13:9 | 4 | 14 |
| 5 |
|
Gallos Blancos | 10 | 3 | 3 | 4 | 14:13 | 1 | 12 |
| 6 |
|
CF América | 9 | 3 | 2 | 4 | 17:17 | 0 | 11 |
| 7 |
|
Cruz Azul | 10 | 3 | 2 | 5 | 17:23 | -6 | 11 |
| 8 |
|
Puebla FC | 10 | 2 | 1 | 7 | 12:20 | -8 | 7 |
| 9 |
|
FC Juárez | 10 | 2 | 0 | 8 | 13:36 | -23 | 6 |
| 2 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Tijuana | 10 | 8 | 1 | 1 | 31:9 | 22 | 25 |
| 2 |
|
CF Monterrey | 9 | 6 | 3 | 0 | 27:11 | 16 | 21 |
| 3 |
|
Deportivo Guadalajara | 10 | 5 | 1 | 4 | 20:14 | 6 | 16 |
| 4 |
|
Atlas Guadalajara | 10 | 4 | 3 | 3 | 22:15 | 7 | 15 |
| 5 |
|
UANL Tigres | 9 | 4 | 2 | 3 | 14:18 | -4 | 14 |
| 6 |
|
Club León | 10 | 4 | 1 | 5 | 17:13 | 4 | 13 |
| 7 |
|
Santos Laguna | 10 | 3 | 3 | 4 | 23:19 | 4 | 12 |
| 8 |
|
Atlético San Luis | 10 | 2 | 0 | 8 | 12:41 | -29 | 6 |
| 9 |
|
Mazatlán FC | 10 | 1 | 0 | 9 | 11:37 | -26 | 3 |
| Playoffs | |
| Playoffs |
