| 1. Round | 25/07/2021 | Pumas UNAM [U18] | - | Atlas Guadalajara [U18] | 1:2 | ||||
| 2. Round | 31/07/2021 | CF Monterrey [U18] | - | Pumas UNAM [U18] | 1:2 |  |
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| 3. Round | 08/08/2021 | Pumas UNAM [U18] | - | Atlético San Luis [U18] | 1:1 | ||||
| 4. Round | 14/08/2021 | Pumas UNAM [U18] | - | Gallos Blancos [U18] | 0:0 | ||||
| 5. Round | 17/08/2021 | Club Necaxa [U18] | - | Pumas UNAM [U18] | 4:2 |  |
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| 6. Round | 22/08/2021 | Pumas UNAM [U18] | - | Puebla FC [U18] | 3:3 | ||||
| 7. Round | 29/08/2021 | Deportivo Toluca [U18] | - | Pumas UNAM [U18] | 2:0 | ||||
| 8. Round | 12/09/2021 | Pumas UNAM [U18] | - | Deportivo Guadalajara [U18] | 1:1 | ||||
| 9. Round | 18/09/2021 | Mazatlán FC [U18] | - | Pumas UNAM [U18] | 2:0 |  |
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| 12. Round | 03/10/2021 | CF América [U18] | - | Pumas UNAM [U18] | 1:0 | ||||
| 13. Round | 17/10/2021 | Pumas UNAM [U18] | - | FC Juárez [U18] | 2:0 | ||||
| 14. Round | 20/10/2021 | Club León [U18] | - | Pumas UNAM [U18] | 2:1 |
Mexico