| Group 2 | 28/02/2018 | Colo-Colo | - | Atlético Nacional | 0:1 |  |
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| Group 2 | 14/03/2018 | Bolívar | - | Colo-Colo | 1:1 | ||||
| Group 2 | 05/04/2018 | Colo-Colo | - | Delfín SC | 0:2 | ||||
| Group 2 | 03/05/2018 | Delfín SC | - | Colo-Colo | 1:2 | |
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| Group 2 | 16/05/2018 | Colo-Colo | - | Bolívar | 2:0 | |
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| Group 2 | 25/05/2018 | Atlético Nacional | - | Colo-Colo | 0:0 | ||||
| Round of 16 | 09/08/2018 | Colo-Colo | - | Corinthians SP | 1:0 | |
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| Round of 16 | 30/08/2018 | Corinthians SP | - | Colo-Colo | 2:1 | ||||
| Quarter-finals | 21/09/2018 | Colo-Colo | - | Palmeiras | 0:2 | |
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| Quarter-finals | 04/10/2018 | Palmeiras | - | Colo-Colo | 2:0 |
Chile