| 3. Round | 03/02/2019 | San Lorenzo | - | Club Nacional | 1:0 | ||||
| 4. Round | 07/02/2019 | Club Nacional | - | Sportivo Luqueño | 0:1 |  |
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| 6. Round | 18/02/2019 | Club Nacional | - | Sol de América | 0:1 |  |
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| 7. Round | 22/02/2019 | Cerro Porteño | - | Club Nacional | 1:1 | |
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| 9. Round | 03/03/2019 | Deportivo Capiatá | - | Club Nacional | 1:0 | |
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| 10. Round | 11/03/2019 | Club Nacional | - | General Díaz | 1:0 | ||||
| 12. Round | 24/03/2019 | Club Olimpia | - | Club Nacional | 0:0 | ||||
| 13. Round | 31/03/2019 | Guaraní | - | Club Nacional | 2:2 | ||||
| 16. Round | 15/04/2019 | Club Nacional | - | Deportivo Santaní | 0:0 | ||||
| 18. Round | 29/04/2019 | Club Nacional | - | Cerro Porteño | 0:3 | |
Argentina