| 1. Round | 31/01/2010 | Atlético Tucumán | - | San Lorenzo | 0:1 | ||||
| 2. Round | 04/02/2010 | San Lorenzo | - | Godoy Cruz | 0:1 | ||||
| 3. Round | 07/02/2010 | Estudiantes | - | San Lorenzo | 2:0 | ||||
| 4. Round | 14/02/2010 | San Lorenzo | - | Vélez Sarsfield | 0:0 | ||||
| 5. Round | 21/02/2010 | Racing Club | - | San Lorenzo | 1:0 | ||||
| 6. Round | 28/02/2010 | San Lorenzo | - | Tigre | 1:0 |  |
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| 7. Round | 04/03/2010 | River Plate | - | San Lorenzo | 1:0 | |
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| 8. Round | 08/03/2010 | San Lorenzo | - | Chacarita Juniors | 3:1 | ||||
| 9. Round | 14/03/2010 | Rosario Central | - | San Lorenzo | 1:0 | |
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| 10. Round | 20/03/2010 | San Lorenzo | - | Colón de Santa Fe | 2:2 | |
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| 12. Round | 03/04/2010 | San Lorenzo | - | Gimnasia de La Plata | 0:1 | |
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| 15. Round | 18/04/2010 | San Lorenzo | - | Huracán | 3:0 | ||||
| 16. Round | 26/04/2010 | Boca Juniors | - | San Lorenzo | 2:0 | |
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| 17. Round | 02/05/2010 | San Lorenzo | - | Argentinos Juniors | 1:2 | |
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| 18. Round | 10/05/2010 | Lanús | - | San Lorenzo | 3:2 | ||||
| 19. Round | 14/05/2010 | San Lorenzo | - | Newell's Old Boys | 2:1 |
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