| 6. Round | 28/02/2010 | Club Olimpia | - | Cerro Porteño | 3:2 |  |
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| 7. Round | 07/03/2010 | Sport Colombia | - | Club Olimpia | 0:4 | ||||
| 8. Round | 12/03/2010 | Club Olimpia | - | 3 de Febrero | 1:0 | ||||
| 9. Round | 16/03/2010 | Sol de América | - | Club Olimpia | 2:1 | ||||
| 10. Round | 20/03/2010 | Libertad | - | Club Olimpia | 0:0 | ||||
| 11. Round | 27/03/2010 | Club Olimpia | - | Guaraní | 0:0 | |
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| 13. Round | 10/04/2010 | Tacuary | - | Club Olimpia | 0:4 | ||||
| 14. Round | 16/04/2010 | Club Olimpia | - | Sportivo Luqueño | 2:1 | ||||
| 17. Round | 02/05/2010 | Cerro Porteño | - | Club Olimpia | 0:0 | ||||
| 18. Round | 08/05/2010 | Club Olimpia | - | Sport Colombia | 2:1 |
Paraguay