| 2. Round | 03/02/2010 | Huracán | - | Newell's Old Boys | 2:1 |  |
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| 5. Round | 20/02/2010 | Newell's Old Boys | - | Lanús | 1:1 | ||||
| 6. Round | 28/02/2010 | Newell's Old Boys | - | Banfield | 2:1 | |
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| 7. Round | 04/03/2010 | Atlético Tucumán | - | Newell's Old Boys | 1:1 | ||||
| 8. Round | 07/03/2010 | Newell's Old Boys | - | Godoy Cruz | 2:1 | ||||
| 9. Round | 13/03/2010 | Estudiantes | - | Newell's Old Boys | 2:0 | ||||
| 4. Round | 17/03/2010 | Argentinos Juniors | - | Newell's Old Boys | 1:1 | ||||
| 10. Round | 20/03/2010 | Newell's Old Boys | - | Vélez Sarsfield | 1:1 | ||||
| 11. Round | 27/03/2010 | Racing Club | - | Newell's Old Boys | 1:0 | ||||
| 12. Round | 03/04/2010 | Newell's Old Boys | - | Tigre | 0:2 | ||||
| 13. Round | 07/04/2010 | River Plate | - | Newell's Old Boys | 0:1 | ||||
| 14. Round | 10/04/2010 | Newell's Old Boys | - | Chacarita Juniors | 3:0 | |
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| 15. Round | 18/04/2010 | Rosario Central | - | Newell's Old Boys | 1:1 |  |
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| 18. Round | 08/05/2010 | Newell's Old Boys | - | Gimnasia de La Plata | 6:0 | ||||
| 19. Round | 14/05/2010 | San Lorenzo | - | Newell's Old Boys | 2:1 |
Argentina