| 1. Round | 16/07/2021 | Huracán II | - | Defensa y Justicia II | 3:0 |  |
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| 3. Round | 27/07/2021 | Huracán II | - | Colón de Santa Fe II | 0:1 | ||||
| 4. Round | 30/07/2021 | River Plate II | - | Huracán II | 2:0 | ||||
| 5. Round | 06/08/2021 | Huracán II | - | Lanús II | 0:2 | ||||
| 8. Round | 25/08/2021 | Huracán II | - | Vélez Sarsfield II | 2:2 | ||||
| 9. Round | 30/08/2021 | Gimnasia de La Plata II | - | Huracán II | 2:0 | ||||
| 10. Round | 03/09/2021 | Huracán II | - | Aldosivi II | 2:1 | ||||
| 12. Round | 17/09/2021 | Huracán II | - | Independiente II | 2:0 | ||||
| 13. Round | 24/09/2021 | Newell's Old Boys II | - | Huracán II | 2:0 | ||||
| 14. Round | 30/09/2021 | Huracán II | - | Arsenal de Sarandí II | 1:0 | ||||
| 15. Round | 08/10/2021 | Central Córdoba SdE II | - | Huracán II | 2:1 | ||||
| 16. Round | 13/10/2021 | Huracán II | - | Boca Juniors II | 1:2 | ||||
| 17. Round | 18/10/2021 | Banfield II | - | Huracán II | 1:2 | ||||
| 18. Round | 22/10/2021 | Huracán II | - | San Lorenzo II | 0:1 | ||||
| 19. Round | 31/10/2021 | Talleres de Córdoba II | - | Huracán II | 0:0 | ||||
| 22. Round | 23/11/2021 | Huracán II | - | Patronato de Paraná II | 1:0 |
Paraguay