| 1. Round | 25/06/2022 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:1 | ||||
| 2. Round | 03/07/2022 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 1:3 |  |
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| 3. Round | 09/07/2022 | UANL Tigres [] | - | Deportivo Guadalajara [] | 0:1 | ||||
| 4. Round | 16/07/2022 | Deportivo Guadalajara [] | - | Club León [] | 2:1 | ||||
| 6. Round | 31/07/2022 | Club Tijuana [] | - | Deportivo Guadalajara [] | 3:1 | ||||
| 7. Round | 06/08/2022 | Deportivo Guadalajara [] | - | CF Monterrey [] | 0:1 | ||||
| 8. Round | 13/08/2022 | Atlético San Luis [] | - | Deportivo Guadalajara [] | 2:1 | ||||
| 9. Round | 20/08/2022 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 4:1 | ||||
| 10. Round | 28/08/2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 1:1 | ||||
| 14. Round | 25/09/2022 | Deportivo Guadalajara [] | - | Club Tijuana [] | 2:1 | ||||
| 16. Round | 08/10/2022 | Club León [] | - | Deportivo Guadalajara [] | 1:1 | ||||
| 17. Round | 15/10/2022 | Deportivo Guadalajara [] | - | UANL Tigres [] | 6:1 | ||||
| 18. Round | 22/10/2022 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 1:0 |
Mexico