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| 15/10/2022 | 17:00 | Puebla FC | - | Club Necaxa | 1:5 (1:0) | |
| 17:15 | Deportivo Guadalajara | - | UANL Tigres | 6:1 (3:0) | ||
| 17:30 | Cruz Azul | - | Deportivo Toluca | 0:2 (0:2) | ||
| 17:45 | Atlético San Luis | - | Mazatlán FC | 2:2 (1:1) | ||
| 18:15 | FC Juárez | - | CF Pachuca | 2:2 (1:1) | ||
| 18:45 | CF América | - | Pumas UNAM | 2:1 (0:1) | ||
| 20:45 | Club Tijuana | - | Atlas Guadalajara | 2:0 (2:0) | ||
| 22:00 | CF Monterrey | - | Santos Laguna | 1:1 (0:1) |
| » Tables | Home | Away | First round | Second round |
| 1 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 15 | 11 | 2 | 2 | 38:17 | 21 | 35 |
| 2 |
|
Club Necaxa | 15 | 8 | 3 | 4 | 31:12 | 19 | 27 |
| 3 |
|
Deportivo Toluca | 15 | 8 | 3 | 4 | 31:20 | 11 | 27 |
| 4 |
|
CF América | 15 | 7 | 3 | 5 | 29:26 | 3 | 24 |
| 5 |
|
CF Pachuca | 15 | 5 | 8 | 2 | 24:16 | 8 | 23 |
| 6 |
|
Cruz Azul | 15 | 4 | 5 | 6 | 24:27 | -3 | 17 |
| 7 |
|
Gallos Blancos | 15 | 3 | 5 | 7 | 18:21 | -3 | 14 |
| 8 |
|
FC Juárez | 16 | 3 | 2 | 11 | 19:58 | -39 | 11 |
| 9 |
|
Puebla FC | 15 | 2 | 3 | 10 | 18:35 | -17 | 9 |
| 2 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Tijuana | 15 | 10 | 2 | 3 | 41:15 | 26 | 32 |
| 2 |
|
Deportivo Guadalajara | 15 | 9 | 2 | 4 | 34:18 | 16 | 29 |
| 3 |
|
CF Monterrey | 15 | 7 | 7 | 1 | 38:22 | 16 | 28 |
| 4 |
|
Santos Laguna | 15 | 7 | 4 | 4 | 35:22 | 13 | 25 |
| 5 |
|
UANL Tigres | 15 | 7 | 3 | 5 | 26:30 | -4 | 24 |
| 6 |
|
Atlas Guadalajara | 15 | 6 | 3 | 6 | 30:24 | 6 | 21 |
| 7 |
|
Club León | 15 | 6 | 3 | 6 | 26:21 | 5 | 21 |
| 8 |
|
Atlético San Luis | 16 | 2 | 1 | 13 | 17:62 | -45 | 7 |
| 9 |
|
Mazatlán FC | 15 | 1 | 1 | 13 | 16:49 | -33 | 4 |
| Playoffs | |
| Playoffs |
