| 3. Round | 18/07/2015 | Sol de América | - | San Lorenzo | 1:2 |  |
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| 4. Round | 25/07/2015 | San Lorenzo | - | Cerro Porteño | 1:1 | ||||
| 5. Round | 02/08/2015 | Deportivo Capiatá | - | San Lorenzo | 0:4 | ||||
| 6. Round | 09/08/2015 | San Lorenzo | - | Club Rubio Ñu | 1:1 | ||||
| 7. Round | 16/08/2015 | Deportivo Santaní | - | San Lorenzo | 2:1 | |
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| 8. Round | 22/08/2015 | General Díaz | - | San Lorenzo | 1:1 | |
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| 9. Round | 30/08/2015 | San Lorenzo | - | Club Olimpia | 1:1 | |
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| 10. Round | 05/09/2015 | Sportivo Luqueño | - | San Lorenzo | 2:1 | ||||
| 11. Round | 13/09/2015 | San Lorenzo | - | Libertad | 0:2 | ||||
| 12. Round | 21/09/2015 | San Lorenzo | - | Guaraní | 2:2 | ||||
| 13. Round | 29/09/2015 | Club Nacional | - | San Lorenzo | 0:2 | ||||
| 14. Round | 04/10/2015 | San Lorenzo | - | Sol de América | 2:4 | |
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| 15. Round | 18/10/2015 | Cerro Porteño | - | San Lorenzo | 1:0 | ||||
| 16. Round | 25/10/2015 | San Lorenzo | - | Deportivo Capiatá | 1:5 | |
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| 17. Round | 31/10/2015 | Club Rubio Ñu | - | San Lorenzo | 3:0 | ||||
| 20. Round | 21/11/2015 | Club Olimpia | - | San Lorenzo | 3:2 | |
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| 21. Round | 30/11/2015 | San Lorenzo | - | Sportivo Luqueño | 2:2 |  |
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