| 1. Round | 08/08/2010 | Gimnasia de La Plata | - | San Lorenzo | 0:0 | ||||
| 2. Round | 15/08/2010 | San Lorenzo | - | Godoy Cruz | 2:2 |  |
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| 3. Round | 22/08/2010 | Racing Club | - | San Lorenzo | 1:2 | ||||
| 4. Round | 29/08/2010 | San Lorenzo | - | All Boys | 3:1 | |
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| 5. Round | 04/09/2010 | Boca Juniors | - | San Lorenzo | 1:2 | ||||
| 6. Round | 11/09/2010 | San Lorenzo | - | Vélez Sarsfield | 0:0 | |
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| 7. Round | 18/09/2010 | San Lorenzo | - | Olimpo de Bahía Blanca | 3:1 | |
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| 12. Round | 24/10/2010 | Huracán | - | San Lorenzo | 3:0 | ||||
| 13. Round | 07/11/2010 | San Lorenzo | - | Independiente | 1:1 | |
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| 14. Round | 14/11/2010 | Argentinos Juniors | - | San Lorenzo | 1:0 | ||||
| 15. Round | 21/11/2010 | San Lorenzo | - | River Plate | 0:0 | ||||
| 16. Round | 27/11/2010 | Arsenal de Sarandí | - | San Lorenzo | 2:1 | |
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| 17. Round | 05/12/2010 | San Lorenzo | - | Newell's Old Boys | 0:0 | ||||
| 18. Round | 10/12/2010 | Quilmes | - | San Lorenzo | 1:0 | |
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| 19. Round | 12/12/2010 | San Lorenzo | - | Banfield | 2:1 |
Argentina