| 2. Round | 21/07/2022 | Tacuary | - | Cerro Porteño | 0:1 |  |
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| 3. Round | 24/07/2022 | Cerro Porteño | - | Sol de América | 2:0 | ||||
| 4. Round | 30/07/2022 | Sportivo Ameliano | - | Cerro Porteño | 0:2 | ||||
| 13. Round | 25/09/2022 | Cerro Porteño | - | Tacuary | 5:0 | ||||
| 18. Round | 23/10/2022 | Guaraní | - | Cerro Porteño | 1:2 | ||||
| 19. Round | 28/10/2022 | Cerro Porteño | - | General Caballero DJLM | 2:1 |
Paraguay