| 2. Round | 16/08/2008 | Independiente | - | San Martín de Tucumán | 1:0 |  |
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| 3. Round | 24/08/2008 | Racing Club | - | Independiente | 1:1 | |
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| 4. Round | 31/08/2008 | Independiente | - | Gimnasia de La Plata | 1:1 |  |
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| 5. Round | 14/09/2008 | Boca Juniors | - | Independiente | 1:1 | ||||
| 6. Round | 17/09/2008 | Independiente | - | Gimnasia de Jujuy | 3:2 | ||||
| 7. Round | 21/09/2008 | Newell's Old Boys | - | Independiente | 1:0 | |
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| 9. Round | 05/10/2008 | Huracán | - | Independiente | 1:0 | |
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| 11. Round | 26/10/2008 | Independiente | - | Argentinos Juniors | 1:1 | ||||
| 12. Round | 28/10/2008 | Tigre | - | Independiente | 1:0 | ||||
| 13. Round | 31/10/2008 | Independiente | - | Godoy Cruz | 1:1 | ||||
| 14. Round | 08/11/2008 | Estudiantes | - | Independiente | 1:0 | ||||
| 15. Round | 16/11/2008 | Independiente | - | River Plate | 0:1 | ||||
| 16. Round | 22/11/2008 | Rosario Central | - | Independiente | 1:2 |  |
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| 17. Round | 28/11/2008 | Independiente | - | Banfield | 0:1 | |
Argentina