1. Round | 06/02/2022 | Real Santa Cruz | - | Universitario de Sucre | 0:1 | ||||
2. Round | 13/02/2022 | Real Santa Cruz | - | CD Guabirá | 2:2 | ||||
4. Round | 26/02/2022 | Real Santa Cruz | - | The Strongest | 1:2 | ||||
5. Round | 06/03/2022 | Real Santa Cruz | - | Club Aurora | 2:2 | ||||
6. Round | 12/03/2022 | Real Santa Cruz | - | Always Ready | 0:1 | ||||
7. Round | 02/04/2022 | Real Santa Cruz | - | Oriente Petrolero | 2:1 | ||||
9. Round | 16/04/2022 | Universitario de Sucre | - | Real Santa Cruz | 2:3 | ||||
10. Round | 21/04/2022 | CD Guabirá | - | Real Santa Cruz | 1:0 | ||||
11. Round | 24/04/2022 | Real Santa Cruz | - | Nacional Potosí | 3:2 |