| 1. Round | 24/07/2021 | CF Pachuca [U20] | - | Club León [U20] | 0:1 |  |
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| 2. Round | 30/07/2021 | Mazatlán FC [U20] | - | CF Pachuca [U20] | 1:1 | |
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| 3. Round | 09/08/2021 | CF Pachuca [U20] | - | Atlas Guadalajara [U20] | 1:1 | ||||
| 4. Round | 14/08/2021 | CF Monterrey [U20] | - | CF Pachuca [U20] | 1:1 | ||||
| 6. Round | 22/08/2021 | Gallos Blancos [U20] | - | CF Pachuca [U20] | 1:2 | ||||
| 7. Round | 29/08/2021 | Cruz Azul [U20] | - | CF Pachuca [U20] | 0:0 | ||||
| 8. Round | 13/09/2021 | CF Pachuca [U20] | - | Deportivo Toluca [U20] | 2:0 | ||||
| 11. Round | 28/09/2021 | CF Pachuca [U20] | - | CF América [U20] | 1:2 | ||||
| 12. Round | 01/10/2021 | Puebla FC [U20] | - | CF Pachuca [U20] | 1:1 | ||||
| 14. Round | 20/10/2021 | UANL Tigres [U20] | - | CF Pachuca [U20] | 2:1 | ||||
| 15. Round | 25/10/2021 | CF Pachuca [U20] | - | FC Juárez [U20] | 6:0 |  |
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| 16. Round | 30/10/2021 | CF Pachuca [U20] | - | Pumas UNAM [U20] | 1:0 | ||||
| 5. Round | 03/11/2021 | CF Pachuca [U20] | - | Atlético San Luis [U20] | 1:3 | ||||
| 17. Round | 10/11/2021 | Club Tijuana [U20] | - | CF Pachuca [U20] | 2:1 |
Mexico