| 3. Round | 12/02/2011 | Club Olimpia | - | General Caballero ZC | 3:1 |  |
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| 4. Round | 16/02/2011 | General Caballero ZC | - | Independiente CG | 1:2 | ||||
| 6. Round | 27/02/2011 | Sol de América | - | General Caballero ZC | 1:2 | ||||
| 7. Round | 06/03/2011 | General Caballero ZC | - | Sportivo Luqueño | 1:0 | ||||
| 9. Round | 12/03/2011 | General Caballero ZC | - | Guaraní | 0:1 | ||||
| 8. Round | 16/03/2011 | Cerro Porteño | - | General Caballero ZC | 2:2 | |
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| 10. Round | 20/03/2011 | Tacuary | - | General Caballero ZC | 1:1 | ||||
| 11. Round | 27/03/2011 | General Caballero ZC | - | Club Rubio Ñu | 1:5 | |
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| 12. Round | 02/04/2011 | General Caballero ZC | - | Libertad | 0:1 | ||||
| 13. Round | 10/04/2011 | 3 de Febrero | - | General Caballero ZC | 1:0 | ||||
| 16. Round | 28/04/2011 | General Caballero ZC | - | Club Nacional | 1:3 | ||||
| 22. Round | 03/06/2011 | Club Rubio Ñu | - | General Caballero ZC | 1:0 |
Paraguay