| 1. Round | 12/02/2021 | Unión de Santa Fe II | - | Atlético Tucumán II | 2:1 |  |
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| 2. Round | 19/02/2021 | Huracán II | - | Unión de Santa Fe II | 2:2 | ||||
| 6. Round | 19/03/2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 3:1 | ||||
| 7. Round | 29/03/2021 | Unión de Santa Fe II | - | Sarmiento de Junín II | 0:2 | ||||
| 8. Round | 02/04/2021 | Vélez Sarsfield II | - | Unión de Santa Fe II | 1:2 | ||||
| 9. Round | 09/04/2021 | Unión de Santa Fe II | - | Boca Juniors II | 2:3 | |
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| 10. Round | 16/04/2021 | Talleres de Córdoba II | - | Unión de Santa Fe II | 0:0 |
Argentina