| 1. Round | 12/02/2021 | Estudiantes II | - | River Plate II | 1:3 | ||||
| 2. Round | 19/02/2021 | River Plate II | - | Rosario Central II | 1:1 | ||||
| 3. Round | 26/02/2021 | Platense II | - | River Plate II | 1:2 | ||||
| 8. Round | 02/04/2021 | Arsenal de Sarandí II | - | River Plate II | 1:1 | ||||
| 10. Round | 16/04/2021 | Central Córdoba SdE II | - | River Plate II | 1:2 | ||||
| 11. Round | 23/04/2021 | River Plate II | - | San Lorenzo II | 2:1 |  |
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| 12. Round | 30/04/2021 | Banfield II | - | River Plate II | 1:2 | |
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| 13. Round | 07/05/2021 | River Plate II | - | Aldosivi II | 3:3 | |
Argentina